Deichmann Richard, Lavie Carl, Andrews Samuel
Ochsner J. 2010 Spring;10(1):16-21.
Coenzyme Q10 is an important factor in mitochondrial respiration. Primary and secondary deficiencies of coenzyme Q10 result in a number of neurologic and myopathic syndromes. Hydroxyl-methylglutaryl coenzyme A reductase inhibitors or statins interfere with the production of mevalonic acid, which is a precursor in the synthesis of coenzyme Q10. The statin medications routinely result in lower coenzyme Q10 levels in the serum. Some studies have also shown reduction of coenzyme Q10 in muscle tissue. Such coenzyme Q10 deficiency may be one mechanism for statin-induced myopathies. However, coenzyme Q10 supplements have not been shown to routinely improve muscle function. Additional research in this area is warranted and discussed in this review.
辅酶Q10是线粒体呼吸的一个重要因素。辅酶Q10的原发性和继发性缺乏会导致多种神经和肌病综合征。羟甲基戊二酰辅酶A还原酶抑制剂或他汀类药物会干扰甲羟戊酸的生成，而甲羟戊酸是辅酶Q10合成的前体。他汀类药物通常会导致血清中辅酶Q10水平降低。一些研究还表明肌肉组织中的辅酶Q10减少。这种辅酶Q10缺乏可能是他汀类药物诱发肌病的一种机制。然而，尚未证明补充辅酶Q10能常规改善肌肉功能。该领域需要更多研究，本文对此进行了讨论。
