癌症干细胞的放射抵抗性和富集：一线放射疗法在肺癌和食管癌中可能失效的地方。
Cancer stem cell radioresistance and enrichment: where frontline radiation therapy may fail in lung and esophageal cancers.
机构信息
Balliol College, University of Oxford, Oxford, UK.
出版信息
Cancers (Basel). 2011 Mar;3(1):1232-52. doi: 10.3390/cancers3011232.
Many studies have highlighted the role cancer stem cells (CSC) play in the development and progression of various types of cancer including lung and esophageal cancer. More recently, it has been proposed that the presence of CSCs affects treatment efficacy and patient prognosis. In reviewing this new area of cancer biology, we will give an overview of the current literature regarding lung and esophageal CSCs and radioresistance of CSC, and discuss the potential therapeutic applications of these findings.
许多研究强调了癌症干细胞 (CSC) 在各种类型癌症（包括肺癌和食管癌）的发展和进展中所起的作用。最近，有人提出 CSCs 的存在会影响治疗效果和患者预后。在回顾这一新的癌症生物学领域时，我们将概述目前关于肺癌和食管癌 CSC 以及 CSC 放射抵抗性的文献，并讨论这些发现的潜在治疗应用。
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