Department of Medicine (Division of Nephrology), Vanderbilt University Medical Center, Nashville, TN, USA.
Pediatr Nephrol. 2012 Jun;27(6):891-900. doi: 10.1007/s00467-011-1890-1. Epub 2011 May 21.
The kidney develops from direct interactions between the ureteric bud and the metanephric mesenchyme. The ureteric bud gives rise to the collecting system and the metanephric mesenchyme to the nephrons. The complex process of renal development which occurs between these embryologically distinct structures is mediated by numerous factors, including the communication of cells with their surrounding extracellular matrix. Integrins are the principal cellular receptors for extracellular matrix proteins, and they play a role in organ and tissue development. In this review we focus on how integrins regulate renal development.
肾脏由输尿管芽和后肾间充质之间的直接相互作用发育而来。输尿管芽产生集合系统，后肾间充质产生肾单位。发生在这些胚胎学上不同结构之间的复杂肾脏发育过程由许多因素介导，包括细胞与其周围细胞外基质的通讯。整合素是细胞外基质蛋白的主要细胞受体，它们在器官和组织发育中发挥作用。在这篇综述中，我们重点关注整合素如何调节肾脏发育。
