Department of Radiation Oncology, "G. d'Annunzio" University of Chieti, SS. Annunziata Hospital, Chieti, Italy.
Strahlenther Onkol. 2011 Jun;187(6):357-66. doi: 10.1007/s00066-011-2221-y. Epub 2011 May 16.
To determine interobserver variability in clinical target volume (CTV) of supra-diaphragmatic Hodgkin's lymphoma.
At the 2008 AIRO (Italian Society of Radiation Oncology) Meeting, the Radiation Oncology Department of Chieti proposed a multi-institutional contouring dummy-run of two cases of early stage supra-diaphragmatic Hodgkin's lymphoma after chemotherapy. Clinical history, diagnostics, and planning CT imaging were available on Chieti's radiotherapy website (www.radioterapia.unich.it). Participating centers were requested to delineate the CTV and submit it to the coordinating center. To quantify interobserver variability of CTV delineations, the total volume, craniocaudal, laterolateral, and anteroposterior diameters were calculated.
A total of 18 institutions for case A and 15 institutions for case B submitted the targets. Case A presented significant variability in total volume (range: 74.1-1,157.1 cc), craniocaudal (range: 6.5-22.5 cm; median: 16.25 cm), anteroposterior (range: 5.04-14.82 cm; median: 10.28 cm), and laterolateral diameters (range: 8.23-22.88 cm; median: 15.5 cm). Mean CTV was 464.8 cc (standard deviation: 280.5 cc). Case B presented significant variability in total volume (range: 341.8-1,662 cc), cranio-caudal (range: 8.0-28.5 cm; median: 23 cm), anteroposterior (range: 7.9-1.8 cm; median: 11.1 cm), and laterolateral diameters (range: 12.9-24.0 cm; median: 18.8 cm). Mean CTV was 926.0 cc (standard deviation: 445.7 cc).
This significant variability confirms the need to apply specific guidelines to improve contouring uniformity in Hodgkin's lymphoma.
确定膈上霍奇金淋巴瘤临床靶区（CTV）的观察者间变异性。
在 2008 年 AIRO（意大利放射肿瘤学会）会议上，基耶蒂放射肿瘤学部提出了两个化疗后早期膈上霍奇金淋巴瘤病例的多机构勾画模拟。临床病史、诊断和计划 CT 成像可在基耶蒂放射治疗网站（www.radioterapia.unich.it）上获得。要求参与中心勾画 CTV 并将其提交给协调中心。为了量化 CTV 勾画的观察者间变异性，计算了CTV 的总体积、颅尾、内外径和前后径。
共 18 个机构为病例 A 和 15 个机构为病例 B 提交了靶区。病例 A 的总体积（范围：74.1-1157.1cc）、颅尾（范围：6.5-22.5cm；中位数：16.25cm）、前后（范围：5.04-14.82cm；中位数：10.28cm）和内外径（范围：8.23-22.88cm；中位数：15.5cm）均有显著差异。CTV 的平均体积为 464.8cc（标准差：280.5cc）。病例 B 的总体积（范围：341.8-1662cc）、颅尾（范围：8.0-28.5cm；中位数：23cm）、前后（范围：7.9-1.8cm；中位数：11.1cm）和内外径（范围：12.9-24.0cm；中位数：18.8cm）均有显著差异。CTV 的平均体积为 926.0cc（标准差：445.7cc）。
这种显著的变异性证实需要应用特定的指南来提高霍奇金淋巴瘤的勾画一致性。
