Wu Yongfu, Fu Hui, Zhang Hanbin, Huang Haohai, Chen Miao, Zhang Li, Yang Huiling, Qin Dongyun
Department of Pharmacology, Guangdong Medical College, Zhanjiang, Guangdong, 524023, China.
Tumour Biol. 2014 Jul;35(7):6913-8. doi: 10.1007/s13277-014-1929-6. Epub 2014 Apr 16.
Many studies have evaluated the association between cyclin D1 (CCND1) G870A polymorphism and cervical cancer susceptibility. However, these studies showed inconsistent results. The aim of this study was to derive a more precise estimation of this association. We searched PubMed and Embase for related studies that had been published in English, and ten case-control studies with a total of 2,864 cases and 3,898 controls were finally identified to be eligible studies in the meta-analysis. The association was assessed by summarizing the odds ratios (ORs) with the corresponding 95 % confidence intervals (CIs). Overall, there was no significant association between cyclin D1 (CCND1) G870A polymorphism and cervical cancer risk (for the allele model A vs. G: OR = 1.02, 95 % CI 0.88-1.19, p = 0.76; for the co-dominant model AA vs. GG: OR = 1.03, 95 % CI 0.75-1.41, p = 0.85; for the dominant model AA + GA vs. GG: OR = 1.00, 95 % CI 0.78-1.28, p = 0.99; for the recessive comparison AA vs. GA + GG: OR = 1.06, 95 % CI 0.85-1.32, p = 0.62). In subgroup analysis by ethnicity, no significant difference was found in both Asians and Caucasians. In summary, the present meta-analysis provides evidence that genotypes for the cyclin D1 (CCND1) G870A polymorphism may be not associated with genetic susceptibility of cervical cancer.
许多研究评估了细胞周期蛋白D1（CCND1）G870A多态性与宫颈癌易感性之间的关联。然而，这些研究结果并不一致。本研究的目的是更精确地估计这种关联。我们在PubMed和Embase数据库中检索了以英文发表的相关研究，最终确定了10项病例对照研究，共计2864例病例和3898例对照，纳入荟萃分析。通过汇总比值比（OR）及相应的95%置信区间（CI）来评估这种关联。总体而言，细胞周期蛋白D1（CCND1）G870A多态性与宫颈癌风险之间无显著关联（等位基因模型A与G相比：OR = 1.02，95% CI 0.88 - 1.19，p = 0.76；共显性模型AA与GG相比：OR = 1.03，95% CI 0.75 - 1.41，p = 0.85；显性模型AA + GA与GG相比：OR = 1.00，95% CI 0.78 - 1.28，p = 0.99；隐性比较AA与GA + GG相比：OR = 1.06，95% CI 0.85 - 1.32，p = 0.62）。按种族进行亚组分析时，亚洲人和高加索人之间均未发现显著差异。总之，本荟萃分析提供的证据表明，细胞周期蛋白D1（CCND1）G870A多态性的基因型可能与宫颈癌的遗传易感性无关。
