表观遗传因素与心脏发育。
Epigenetic factors and cardiac development.
机构信息
Cardiovascular Regeneration, Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan.
出版信息
Cardiovasc Res. 2011 Jul 15;91(2):203-11. doi: 10.1093/cvr/cvr138. Epub 2011 May 23.
Abstract
Congenital heart malformations remain the leading cause of death related to birth defects. Recent advances in developmental and regenerative cardiology have shed light on a mechanistic understanding of heart development that is controlled by a transcriptional network of genetic and epigenetic factors. This article reviews the roles of chromatin remodelling factors important for cardiac development with the current knowledge of cardiac morphogenesis, regeneration, and direct cardiac differentiation. In the last 5 years, critical roles of epigenetic factors have been revealed in the cardiac research field.
摘要
先天性心脏畸形仍然是与出生缺陷相关的主要死亡原因。最近在发育和再生心脏病学方面的进展揭示了一个心脏发育的机制性理解，该理解受遗传和表观遗传因素的转录网络控制。本文综述了染色质重塑因子在心脏发育中的作用，以及当前对心脏形态发生、再生和直接心脏分化的认识。在过去的 5 年中，表观遗传因素在心脏研究领域的关键作用已经被揭示。
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