探究心血管发育的转录调控。
Investigating the transcriptional control of cardiovascular development.
作者信息
Kathiriya Irfan S, Nora Elphège P, Bruneau Benoit G
机构信息
From the Gladstone Institute of Cardiovascular Disease and the Roddenberry Center for Stem Cell Biology and Medicine at Gladstone, San Francisco, CA (I.S.K., E.P.N., B.G.B.); and Department of Anesthesia and Perioperative Care (I.S.K.), Department of Pediatrics (B.G.B.), Cardiovascular Research Institute (B.G.B.), and Institute for Regeneration Medicine (B.G.B.), University of California, San Francisco.
出版信息
Circ Res. 2015 Feb 13;116(4):700-14. doi: 10.1161/CIRCRESAHA.116.302832.
Transcriptional regulation of thousands of genes instructs complex morphogenetic and molecular events for heart development. Cardiac transcription factors choreograph gene expression at each stage of differentiation by interacting with cofactors, including chromatin-modifying enzymes, and by binding to a constellation of regulatory DNA elements. Here, we present salient examples relevant to cardiovascular development and heart disease, and review techniques that can sharpen our understanding of cardiovascular biology. We discuss the interplay between cardiac transcription factors, cis-regulatory elements, and chromatin as dynamic regulatory networks, to orchestrate sequential deployment of the cardiac gene expression program.
数千个基因的转录调控指导着心脏发育过程中复杂的形态发生和分子事件。心脏转录因子通过与包括染色质修饰酶在内的辅因子相互作用，并结合一系列调控性DNA元件，在分化的每个阶段编排基因表达。在这里，我们展示与心血管发育和心脏病相关的显著例子，并回顾能够加深我们对心血管生物学理解的技术。我们讨论心脏转录因子、顺式调控元件和染色质之间的相互作用，将其作为动态调控网络，以协调心脏基因表达程序的顺序部署。
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