靶向足细胞。
The targeted podocyte.
机构信息
Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.
出版信息
J Clin Invest. 2011 Jun;121(6):2142-5. doi: 10.1172/JCI57935. Epub 2011 May 23.
Abstract
The podocyte plays a key role both in maintenance of the glomerular filtration barrier and in glomerular structural integrity. Podocyte injury and loss contribute to proteinuria and progressive sclerosis. Inhibitors of mammalian target of rapamycin (mTOR) have variably decreased or caused proteinuria and sclerosis in human disease and experimental settings. In this issue of the JCI, two interesting studies of podocyte-specific manipulation of the mTOR system shed light on the complexity of this pathway in the podocyte.
摘要
足细胞在维持肾小球滤过屏障和肾小球结构完整性方面发挥着关键作用。足细胞损伤和丢失导致蛋白尿和进行性硬化。哺乳动物雷帕霉素靶蛋白（mTOR）抑制剂在人类疾病和实验环境中不同程度地减少或导致蛋白尿和硬化。在本期 JCI 中，两项关于足细胞特异性 mTOR 系统操作的有趣研究揭示了该途径在足细胞中的复杂性。
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本文引用的文献
1
mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice.在小鼠糖尿病肾病的发生发展中，足细胞中 mTORC1 的激活是一个关键步骤。
J Clin Invest. 2011 Jun;121(6):2181-96. doi: 10.1172/JCI44771. Epub 2011 May 23.
2
Role of mTOR in podocyte function and diabetic nephropathy in humans and mice.mTOR 在人及小鼠足细胞功能和糖尿病肾病中的作用。
J Clin Invest. 2011 Jun;121(6):2197-209. doi: 10.1172/JCI44774. Epub 2011 May 23.
3
Mouse models of diabetic nephropathy.糖尿病肾病的小鼠模型。
Curr Opin Nephrol Hypertens. 2011 May;20(3):278-84. doi: 10.1097/MNH.0b013e3283451901.
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Glomerular sclerosis is prevented during urinary tract obstruction due to podocyte protection.肾小球硬化在由于足细胞保护而导致的尿路梗阻期间被预防。
Am J Physiol Renal Physiol. 2011 Mar;300(3):F792-800. doi: 10.1152/ajprenal.00570.2010. Epub 2010 Dec 22.
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