Bell David S H
South Med J. 2011 May;104(5):335-9. doi: 10.1097/01.SMJ.0000397893.94525.0e.
Vitamin D deficiency is epidemic and its manifestations are protean. Vitamin D deficiency is associated with autoimmune diseases (particularly multiple sclerosis and type 1 diabetes) and has been associated with infection, allergy, asthma, and dermopathies (particularly psoriasis). Asthma may be worsened by vitamin D deficiency and correction of the deficiency has been shown to improve the manifestations of asthma. Vitamin D deficiency has been associated with multiple cancers, including those of the breast, colon, ovary, and prostate. Due mainly to increased insulin resistance but also to an impairment in insulin release, vitamin D deficiency is associated with the development of type 2 diabetes. In addition, the complications of diabetes may be worsened by vitamin D deficiency.
维生素D缺乏症极为常见，其表现形式多种多样。维生素D缺乏与自身免疫性疾病（尤其是多发性硬化症和1型糖尿病）相关，还与感染、过敏、哮喘及皮肤病（尤其是牛皮癣）有关。维生素D缺乏可能会使哮喘病情加重，而纠正这种缺乏已被证明可改善哮喘症状。维生素D缺乏与多种癌症相关，包括乳腺癌、结肠癌、卵巢癌和前列腺癌。维生素D缺乏主要由于胰岛素抵抗增加，但也与胰岛素分泌受损有关，它与2型糖尿病的发生相关。此外，维生素D缺乏可能会加重糖尿病的并发症。
