Griz Luiz Henrique Maciel, Bandeira Francisco, Gabbay Mônica Andrade Lima, Dib Sergio Atala, Carvalho Eduardo Freese de
Endocrinology, Diabetes and Bone Diseases Division of Agamenon Magalhães Hospital, Universidade Federal de Pernambuco, Recife, PE, Brazil.
Endocrinology Division and Diabetes Center, Universidade Federal de São Paulo, São Paulo, SP, Brazil.
Arq Bras Endocrinol Metabol. 2014 Feb;58(1):1-8. doi: 10.1590/0004-2730000002535.
Vitamin D deficiency and diabetes mellitus are two common conditions and they are widely prevalent across all ages, races, geographical regions, and socioeconomic conditions. Epidemiologic studies have shown association of vitamin D deficiency and increased risk of chronic diseases, such as cancer, cardiovascular disease, type 2 diabetes, and autoimmune diseases, such as multiple sclerosis and type 1 diabetes mellitus. The identification of 1,25(OH)2D receptors and 1-α-hydroxilase expression in pancreatic beta cells, in cells of the immune system, and in various others tissues, besides the bone system support the role of vitamin D in the pathogenesis of type 2 diabetes. Observational studies have revealed an association between 25(OH) D deficiency and the prevalence of type 1 diabetes in children and adolescents. This review will focus on the concept of vitamin D deficiency, its prevalence, and its role in the pathogenesis and risk of diabetes mellitus and cardiovascular diseases.
维生素D缺乏症和糖尿病是两种常见病症，在所有年龄段、种族、地理区域及社会经济状况中都广泛存在。流行病学研究表明，维生素D缺乏与患慢性疾病（如癌症、心血管疾病、2型糖尿病）以及自身免疫性疾病（如多发性硬化症和1型糖尿病）的风险增加有关。除骨骼系统外，在胰腺β细胞、免疫系统细胞及其他各种组织中发现了1,25(OH)2D受体和1-α-羟化酶的表达，这支持了维生素D在2型糖尿病发病机制中的作用。观察性研究揭示了25(OH)D缺乏与儿童及青少年1型糖尿病患病率之间的关联。本综述将聚焦于维生素D缺乏的概念、其患病率及其在糖尿病和心血管疾病发病机制及风险中的作用。
