Department of Diabetes and Metabolism, The Royal London Hospital, Whitechapel, London, UK.
Postgrad Med J. 2010 Jan;86(1011):18-25; quiz 24. doi: 10.1136/pgmj.2009.078626.
Type 2 diabetes is a major public health problem, accounting for significant premature mortality and morbidity. The growth in prevalence of the condition appears to be closely linked with obesity. Over the last 5 years, a number of large observational studies have suggested an association between the onset of type 2 diabetes and Vitamin D deficiency. Vitamin D has important effects on insulin action, and may impact on a number of pathways which may be of importance in the development of type 2 diabetes. This article reviews the evidence linking Vitamin D deficiency in the pathogenesis of type 2 diabetes, and suggests areas for urgent further research to determine whether Vitamin D replacement has a role in the prevention of type 2 diabetes.
2 型糖尿病是一个主要的公共卫生问题，导致了大量的过早死亡和发病。这种疾病的患病率增长似乎与肥胖密切相关。在过去的 5 年中，一些大型观察性研究表明 2 型糖尿病的发病与维生素 D 缺乏之间存在关联。维生素 D 对胰岛素作用有重要影响，可能影响到一些在 2 型糖尿病发展中具有重要意义的途径。本文综述了维生素 D 缺乏与 2 型糖尿病发病机制之间的关联证据，并提出了迫切需要进一步研究的领域，以确定维生素 D 替代治疗在预防 2 型糖尿病中的作用。
