Rajeswari Ravichandran, Casey K Chan, Michael Raghunath, Division of Bioengineering, Faculty of Engineering, National University of Singapore, Singapore 117574, Singapore.
World J Stem Cells. 2009 Dec 31;1(1):55-66. doi: 10.4252/wjsc.v1.i1.55.
Stem cells are unspecialized cells that can self renew indefinitely and differentiate into several somatic cells given the correct environmental cues. In the stem cell niche, stem cell-extracellular matrix (ECM) interactions are crucial for different cellular functions, such as adhesion, proliferation, and differentiation. Recently, in addition to chemical surface modifications, the importance of nanometric scale surface topography and roughness of biomaterials has increasingly becoming recognized as a crucial factor for cell survival and host tissue acceptance in synthetic ECMs. This review describes the influence of nanotopography on stem cell phenotypes.
干细胞是未特化的细胞，可以在适当的环境信号下无限自我更新并分化为几种体细胞。在干细胞龛中，干细胞-细胞外基质（ECM）的相互作用对于不同的细胞功能至关重要，例如黏附、增殖和分化。最近，除了化学表面修饰外，生物材料的纳米级表面形貌和粗糙度的重要性也越来越被认为是合成 ECM 中细胞存活和宿主组织接受的关键因素。本综述描述了纳米形貌对干细胞表型的影响。
