Basu Partha, Burgmayer Sharon J N
Department of Chemistry and Biochemistry, Duquesne University, Pittsburgh, PA 15282, United States.
Coord Chem Rev. 2011 May;255(9-10):1016-1038. doi: 10.1016/j.ccr.2011.02.010.
The molybdenum cofactor is composed of a molybdenum coordinated by one or two rather complicated ligands known as either molybdopterin or pyranopterin. Pterin is one of a large family of bicyclic N-heterocycles called pteridines. Such molecules are widely found in Nature, having various forms to perform a variety of biological functions. This article describes the basic nomenclature of pterin, their biological roles, structure, chemical synthesis and redox reactivity. In addition, the biosynthesis of pterins and current models of the molybdenum cofactor are discussed.
钼辅因子由一个钼原子与一个或两个相当复杂的配体配位组成，这些配体被称为钼蝶呤或吡喃蝶呤。蝶呤是一大类双环N-杂环化合物（称为蝶啶）中的一种。这类分子在自然界中广泛存在，具有多种形式以执行各种生物学功能。本文描述了蝶呤的基本命名法、它们的生物学作用、结构、化学合成和氧化还原反应性。此外，还讨论了蝶呤的生物合成以及钼辅因子的当前模型。
