Gui-Rong Li, Departments of Medicine and Physiology, Li Ka Shing Faculty of Medicine, the University of Hong Kong, Pokfulam, Hong Kong, China.
World J Stem Cells. 2011 Mar 26;3(3):19-24. doi: 10.4252/wjsc.v3.i3.19.
Bioelectrical signals generated by ion channels play crucial roles in excitation genesis and impulse conduction in excitable cells as well as in cell proliferation, migration and apoptosis in proliferative cells. Recent studies have demonstrated that multiple ion channels are heterogeneously present in different stem cells; however, patterns and phenotypes of ion channels are species- and/or origin-dependent. This editorial review focuses on the recent findings related to the expression of functional ion channels and the roles of these channels in regulation of cell proliferation in stem cells. Additional effort is required in the future to clarify the ion channel expression in different types of stem cells; special attention should be paid to the relationship between ion channels and stem cell proliferation, migration and differentiation.
由离子通道产生的生物电化学信号在可兴奋细胞的兴奋发生和冲动传导中以及在增殖细胞的增殖、迁移和凋亡中发挥着关键作用。最近的研究表明，多种离子通道在不同的干细胞中不均匀存在；然而，离子通道的模式和表型是物种和/或起源依赖性的。本社论评论集中于与功能离子通道的表达以及这些通道在调节干细胞增殖中的作用相关的最新发现。未来需要进一步努力阐明不同类型干细胞中的离子通道表达；应特别注意离子通道与干细胞增殖、迁移和分化之间的关系。
