Department of Cardiology, College of Medicine, The Catholic University of Korea, Bucheon St. Mary' Hospital, Bucheon, Korea.
Korean Circ J. 2011 Apr;41(4):198-202. doi: 10.4070/kcj.2011.41.4.198. Epub 2011 Apr 30.
Adipokines have been suggested for their potential use in tracking the clinical progress in the subjects with metabolic syndrome (MS). To investigate the relationship between the serum levels of adipokines {adiponectin and retinol-binding protein 4 (RBP4)} and the serum level of uric acid in hypertensive (HTN) patients with MS.
In this study, 38 totally untreated HTN patients were enrolled. Anthropometric measurements, blood pressure (BP) were taken in the 12 HTN patients without MS and the 26 HTN patients with MS. Fasting blood samples were collected for measurement of adiponectin, RBP4, nitric oxide (NO), glucose, creatinine, uric acid, lipid profile and insulin.
The HTN with MS group had significant higher values of body mass index, waist length, serum uric acid and triglyceride levels than the HTN without MS group. Compared to the HTN without MS group, the HTN with MS group showed significantly lower adiponectin (p=0.030), NO (p=0.003) and high density lipoprotein levels (p<0.001). Serum adiponectin levels negatively correlated with insulin level (R=-0.453, p=0.026) and uric acid level (R=-0.413, p=0.036), and serum RBP4 levels positively correlated with uric acid level (R=0.527, p=0.006) in the HTN with MS group. Multiple linear regression analysis using RBP4 and adiponectin levels as the dependent variables showed that uric acid level correlated with serum RBP4 level (p=0.046) and adiponectin level (p=0.044).
The HTN with MS group showed a correlation with two types of adipokines (adiponectin, RBP4) and uric acid. Adiponectin, RBP4 and uric acid may be important components associated with MS, especially when associated with hypertension.
脂肪因子因其在代谢综合征（MS）患者的临床进展跟踪方面的潜在应用而受到关注。本研究旨在探讨高血压（HTN）合并 MS 患者血清脂肪因子（脂联素和视黄醇结合蛋白 4[RBP4]）水平与尿酸水平之间的关系。
本研究共纳入 38 例未经治疗的 HTN 患者。12 例无 MS 的 HTN 患者和 26 例 HTN 合并 MS 的患者接受了体格检查、血压（BP）测量。采集空腹血样，用于检测脂联素、RBP4、一氧化氮（NO）、血糖、肌酐、尿酸、血脂和胰岛素。
HTN 合并 MS 组的体重指数、腰围、血清尿酸和甘油三酯水平明显高于 HTN 无 MS 组。与 HTN 无 MS 组相比，HTN 合并 MS 组的脂联素水平显著降低（p=0.030），NO 水平显著降低（p=0.003），高密度脂蛋白水平显著降低（p<0.001）。HTN 合并 MS 组患者血清脂联素水平与胰岛素水平（R=-0.453，p=0.026）和尿酸水平（R=-0.413，p=0.036）呈负相关，血清 RBP4 水平与尿酸水平呈正相关（R=0.527，p=0.006）。以 RBP4 和脂联素水平为因变量进行多元线性回归分析显示，尿酸水平与血清 RBP4 水平（p=0.046）和脂联素水平（p=0.044）相关。
HTN 合并 MS 组与两种类型的脂肪因子（脂联素、RBP4）和尿酸相关。脂联素、RBP4 和尿酸可能是与 MS 相关的重要组成部分，尤其是与高血压相关时。
