Department of Neurology, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah 84132, USA.
Muscle Nerve. 2011 Jun;43(6):780-94. doi: 10.1002/mus.22038.
Chronic inflammatory demyelinating polyradicoloneuropathy (CIDP) is a treatable form of neuropathy. Efforts to devise sets of electrodiagnostic (nerve conduction) criteria to distinguish primary demyelination from primary axonal neuropathies have been elusive, and at least 16 criteria have been proposed. Modifications to criteria frequently represent minor changes based on applying a set to a small number of patients with the clinical diagnosis of CIDP, whereas others are based on physiological changes related to demyelination and other pathophysiological features. The various modifications continue to result in limited sensitivity, likely related to the wide range of nerve conduction abnormalities among CIDP patients. Although some sets are appropriate for formal clinical drug trials, their complexity makes them difficult to apply in the clinic or electromyography laboratory. This study considers the evolution of the criteria, discusses their limitations, and ends with a simplified set of guidelines that can be applied in the clinic or laboratory.
慢性炎症性脱髓鞘性多发性神经病（CIDP）是一种可治疗的神经病。人们一直试图设计一套电诊断（神经传导）标准，以区分原发性脱髓鞘与原发性轴索性神经病，但始终未能如愿，目前已经提出了至少 16 项标准。这些标准的修改通常是基于将一套标准应用于少数具有 CIDP 临床诊断的患者，只是进行了一些细微的改动，而其他标准则基于脱髓鞘和其他病理生理特征相关的生理变化。这些各种修改继续导致敏感性有限，这可能与 CIDP 患者的神经传导异常范围广泛有关。虽然有些标准适用于正式的临床药物试验，但由于其复杂性，在临床或肌电图实验室中难以应用。本研究考虑了这些标准的演变，讨论了它们的局限性，并提出了一套简化的指南，可在临床或实验室中应用。
