Silva Ruwan A, Moshfeghi Andrew A, Kaiser Peter K, Singh Rishi P, Moshfeghi Darius M
Department of Ophthalmology, Stanford University School of Medicine, Stanford, CA, USA.
Semin Ophthalmol. 2011 May;26(3):121-30. doi: 10.3109/08820538.2011.554486.
Age-related macular degeneration (AMD) remains a devastating cause of visual loss among elderly individuals. While considerable progress has been made towards combating the disease, most recently with intravitreal anti-VEGF agents, visual outcomes are still limited by continued retinal pigment epithelium (RPE) degeneration and subsequent neurosensory retinal atrophy. Among the promising new treatment options being explored, radiotherapy appears apt to address the multifactorial etiology of AMD. Current investigative studies underway will hopefully yield clinical efficacy to complement this theoretical suitability for arresting visual loss.
年龄相关性黄斑变性(AMD)仍然是老年人视力丧失的一个毁灭性原因。尽管在对抗这种疾病方面已经取得了相当大的进展,最近使用玻璃体内抗血管内皮生长因子(VEGF)药物,但视力结果仍然受到视网膜色素上皮(RPE)持续退化以及随后的神经感觉性视网膜萎缩的限制。在正在探索的有前景的新治疗选择中,放射治疗似乎适合解决AMD的多因素病因。目前正在进行的研究有望产生临床疗效,以补充这种阻止视力丧失的理论适用性。