Department of Electrical and Computer Engineering, University of Calgary, Calgary, AB, Canada.
Int J Stroke. 2011 Aug;6(4):302-5. doi: 10.1111/j.1747-4949.2010.00579.x. Epub 2011 Jan 28.
Volume measurements of intracerebral haemorrhage are prognostically important and are increasingly used in clinical trials to measure the effects of potential interventions. The purpose of this work is to establish the reliability of haematoma volume measurements obtained using a computer-assisted method called Quantomo (for quantitative tomography) and the ABC/2 method. Hypothesis Quantomo reliably detects smaller changes in intracerebral haemorrhage volume as compared with the ABC/2 method because computer-assisted volume measurements are tailored to measure the geometry of individual haematoma volumes whereas the ABC/2 method approximates all haematoma volumes as ellipsoids.
Thirty randomly selected computed tomography scans with intracerebral haemorrhage were measured by four raters a total of four times each (two sessions using Quantomo and two using the ABC/2 method). Interrater and intrarater reliability for both techniques were calculated simultaneously using a two-way random-effects analysis of variance model. The precision of intracerebral haemorrhage volume measurement was quantified as the minimum detectable difference with 95% confidence intervals.
The median (first quartile and third quartile) intracerebral haemorrhage volume measurements of all rater and sessions for Quantomo were 32.7 ml (6.2 and 54.4 ml) and for ABC/2 40.7 ml (8.6 and 76.0 ml). Quantomo intracerebral haemorrhage volume measurements were more precise, having an inter- and intrarater minimum detectable difference of 8.1 and 5.3 ml, while the inter- and intrarater minimum detectable difference for ABC/2 were 37.0 and 15.7 ml.
Quantomo is a computer-assisted methodology that is more reliable for quantifying intracerebral haemorrhage volume as compared with the ABC/2 method.
颅内血肿体积测量对预后具有重要意义，并且越来越多地用于临床试验来衡量潜在干预措施的效果。本研究旨在验证一种名为 Quantomo（定量断层扫描）的计算机辅助方法和 ABC/2 方法测量血肿体积的可靠性。假说 Quantomo 能够可靠地检测到颅内血肿体积的较小变化，而 ABC/2 方法则因为计算机辅助的体积测量可以根据个体血肿的几何形状进行定制，而 ABC/2 方法则将所有血肿体积近似为椭球体。
共对 30 例随机选择的 CT 扫描颅内出血患者进行了 4 名评估者的总共 4 次测量（Quantomo 方法两次，ABC/2 方法两次）。同时使用双向随机效应方差模型分析计算两种技术的组内和组间可靠性。用 95%置信区间的最小可检测差值定量评估颅内血肿体积测量的精度。
Quantomo 所有评估者和所有测量的中位数（第一四分位数和第三四分位数）颅内血肿体积为 32.7ml（6.2 和 54.4ml），而 ABC/2 为 40.7ml（8.6 和 76.0ml）。Quantomo 颅内血肿体积测量更精确，组内和组间的最小可检测差值分别为 8.1 和 5.3ml，而 ABC/2 的组内和组间的最小可检测差值分别为 37.0 和 15.7ml。
与 ABC/2 方法相比，Quantomo 是一种更可靠的计算机辅助方法，用于定量测量颅内血肿体积。
