Biomedical Research Unit of the Mexican Social Security Institute, Durango, México.
Magnes Res. 2011 Jun;24(2):45-53. doi: 10.1684/mrh.2011.0281.
To evaluate the association between severe hypomagnesemia and the low-grade inflammatory response in subjects with metabolic syndrome (MetS), ninety-eight individuals with new diagnosis of MetS were enrolled in a cross-sectional study. Pregnancy, smoking, alcohol intake, renal damage, hepatic disorders, infectious or chronic inflammatory diseases, malignancy, use of diuretics, statins, calcium antagonist, antioxidants, vitamins, anti-inflammatory drugs, or previous oral magnesium supplementation were exclusion criteria. According serum magnesium levels, participants were assigned to the following groups: 1) severe hypomagnesemia (≤1.2 mg/dL); 2) hypomagnesemia (>1.2≤1.8 mg/dL); 3) Normal serum magnesium levels (>1.8 mg/dL). The low-grade inflammatory response was defined by elevation of serum levels of (hsCRP >1.0 ≤10.0 mg/L) or TNF-alpha (TNF-α ≥3.5 pg/mL). Severe hypomagnesemia, hypomagnesemia, and normomagnesemia were identified in 21 (21.4%), 38 (38.8%), and 39 (39.8%) individuals. The ORs, adjusted by WC, showed that severe hypomagnesemia (OR: 8.1; CI 95%: 3.6-19.4 and OR: 3.7; CI 95%: 1.1-12.1), but not hypomagnesemia (OR: 1.8; CI 95%: 0.9-15.5 and OR: 1.6; CI 95%: 0.7-3.6), was strongly associated with elevated hsCRP and TNF-α levels, and that normomagnesemia exhibited a protective role (OR: 0.32; CI 95%: 0.1-0.7 and OR: 0.28; CI 95%: 0.1-0.6) for elevation of CRP and TNF-α. Results of this study show that, in subjects with MetS, severe hypomagnesemia, but not hypomagnesemia, is associated with elevated concentrations of CRP and TNF-α.
为了评估代谢综合征（MetS）患者严重低镁血症与低度炎症反应之间的关系，对 98 名新诊断为 MetS 的患者进行了一项横断面研究。排除妊娠、吸烟、饮酒、肾损伤、肝疾病、感染或慢性炎症性疾病、恶性肿瘤、利尿剂、他汀类药物、钙拮抗剂、抗氧化剂、维生素、抗炎药或以前口服镁补充剂。根据血清镁水平，将参与者分为以下几组：1）严重低镁血症（≤1.2mg/dL）；2）低镁血症（>1.2≤1.8mg/dL）；3）正常血清镁水平（>1.8mg/dL）。低度炎症反应定义为血清 hsCRP 升高（hsCRP>1.0≤10.0mg/L）或 TNF-α升高（TNF-α≥3.5pg/mL）。21 例（21.4%）、38 例（38.8%）和 39 例（39.8%）患者分别存在严重低镁血症、低镁血症和正常镁血症。经 WC 调整后的 ORs 显示，严重低镁血症（OR：8.1；95%CI：3.6-19.4 和 OR：3.7；95%CI：1.1-12.1），但不是低镁血症（OR：1.8；95%CI：0.9-15.5 和 OR：1.6；95%CI：0.7-3.6）与 hsCRP 和 TNF-α水平升高强烈相关，而正常镁血症表现出保护作用（OR：0.32；95%CI：0.1-0.7 和 OR：0.28；95%CI：0.1-0.6）与 CRP 和 TNF-α升高相关。本研究结果表明，在 MetS 患者中，严重低镁血症，而不是低镁血症，与 CRP 和 TNF-α浓度升高有关。
