Guerrero-Romero Fernando, Flores-García Araceli, Saldaña-Guerrero Stephanie, Simental-Mendía Luis E, Rodríguez-Morán Martha
Biomedical Research Unit, Mexican Social Security Institute, Predio Canoas # 100, Col. Los Angeles, ZC 34067, Durango, Mexico.
Biomedical Research Unit, Mexican Social Security Institute, Predio Canoas # 100, Col. Los Angeles, ZC 34067, Durango, Mexico.
Eur J Intern Med. 2016 Oct;34:29-33. doi: 10.1016/j.ejim.2016.06.015. Epub 2016 Jun 25.
Whether low serum magnesium is an epiphenomenon related with obesity or, whether obesity per se is cause of hypomagnesemia, remains to be clarified.
To examine the relationship between body weight status and hypomagnesemia in apparently healthy subjects.
A total of 681 healthy individuals aged 30 to 65years were enrolled in A cross-sectional study. Extreme exercise, chronic diarrhea, alcohol intake, use of diuretics, smoking, oral magnesium supplementation, diabetes, malnutrition, hypertension, liver disease, thyroid disorders, and renal damage were exclusion criteria. Based in the Body Mass Index (BMI), body weight status was defined as follows: normal weight (BMI <25kg/m); overweight (BMI ≥25<30 BMIkg/m); and obesity (BMI ≥30kg/m). Hypomagnesemia was defined by serum magnesium concentration ≤0.74mmol/L. A multiple logistic regression analysis was used to compute the odds ratio (OR) between body weight status (independent variables) and hypomagnesemia (dependent variable).
The multivariate logistic regression analysis showed that dietary magnesium intake (OR 2.11; 95%CI 1.4-5.7) but no obesity (OR 1.53; 95%CI 0.9-2.5), overweight (OR 1.40; 95%CI 0.8-2.4), and normal weight (OR 0.78; 95%CI 0.6-2.09) were associated with hypomagnesemia. A subsequent logistic regression analysis adjusted by body mass index, waist circumference, total body fat, systolic and diastolic blood pressure, and triglycerides levels showed that hyperglycemia (2.19; 95%CI 1.1-7.0) and dietary magnesium intake (2.21; 95%CI 1.1-8.9) remained associated with hypomagnesemia.
Our results show that body weight status is not associated with hypomagnesemia and that, irrespective of obesity, hyperglycemia is cause of hypomagnesemia in non-diabetic individuals.
低血清镁是与肥胖相关的一种附带现象，还是肥胖本身就是低镁血症的病因，仍有待阐明。
研究看似健康的受试者体重状况与低镁血症之间的关系。
一项横断面研究纳入了681名年龄在30至65岁的健康个体。排除标准包括剧烈运动、慢性腹泻、饮酒、使用利尿剂、吸烟、口服镁补充剂、糖尿病、营养不良、高血压、肝病、甲状腺疾病和肾损伤。根据体重指数（BMI），体重状况定义如下：正常体重（BMI<25kg/m）；超重（BMI≥25<30BMIkg/m）；肥胖（BMI≥30kg/m）。低镁血症定义为血清镁浓度≤0.74mmol/L。采用多元逻辑回归分析计算体重状况（自变量）与低镁血症（因变量）之间的比值比（OR）。
多因素逻辑回归分析显示，膳食镁摄入量（OR 2.11；95%CI 1.4 - 5.7）与低镁血症相关，但肥胖（OR 1.53；95%CI 0.9 - 2.5）、超重（OR 1.40；95%CI 0.8 - 2.4）和正常体重（OR 0.78；95%CI 0.6 - 2.09）与低镁血症无关。随后经体重指数、腰围、体脂总量、收缩压和舒张压以及甘油三酯水平校正的逻辑回归分析显示，高血糖（2.19；95%CI 1.1 - 7.0）和膳食镁摄入量（2.21；95%CI 1.1 - 8.9）仍与低镁血症相关。
我们的结果表明，体重状况与低镁血症无关，并且在非糖尿病个体中，无论是否肥胖，高血糖都是低镁血症的病因。
