Laboratory of Chemistry-Biochemistry-Physical Chemistry of Foods, Department of Dietetics and Nutritional Science, Harokopio University, Athens, Greece.
J Med Food. 2011 Nov;14(11):1403-11. doi: 10.1089/jmf.2010.0240. Epub 2011 May 25.
Mastic (Pistacia lentiscus) of the Anacardiaceae family has exhibited anti-inflammatory and antioxidant properties in patients with Crohn's disease. This study was based on the hypothesis that mastic inhibits intestinal damage in inflammatory bowel disease, regulating inflammation and oxidative stress in intestinal epithelium. Four different dosages of P. lentiscus powder in the form of powder were administered orally to trinitrobenzene sulfonic acid-induced colitic rats. Eighty-four male Wistar rats were randomly assigned to seven groups: A, control; B, colitic; C-F, colitic rats daily supplemented with P. lentiscus powder at (C) 50 mg/kg, (D) 100 mg/kg, (E) 200 mg/kg, and (F) 300 mg/kg of body weight; and G, colitic rats treated daily with cortisone (25 μg/kg of body weight). Colonic damage was assessed microscopically. The cytokines tumor necrosis factor-α, intercellular adhesion molecule-1 (ICAM-1), interleukin (IL)-6, IL-8, and IL-10 and malonaldehyde were measured in colonic specimens. Results were expressed as mean ± SE values. Histological amelioration of colitis (P≤.001) and significant differences in colonic indices occurred after 3 days of treatment. Daily administration of 100 mg of P. lentiscus powder/kg of body weight decreased all inflammatory cytokines (P≤.05), whereas 50 mg of P. lentiscus powder/kg of body weight and cortisone treatment reduced only ICAM-1 (P≤.05 and P≤.01, respectively). Malonaldehyde was significantly suppressed in all treated groups (P≤.01). IL-10 remained unchanged. Cytokines and malonaldehyde remained unaltered after 6 days of treatment. Thus P. lentiscus powder could possibly have a therapeutic role in Crohn's disease, regulating oxidant/antioxidant balance and modulating inflammation.
乳香（乳香属）属于漆树科，已在克罗恩病患者中显示出抗炎和抗氧化特性。本研究基于乳香可抑制炎症性肠病中肠道损伤的假说，调节肠道上皮的炎症和氧化应激。以粉末形式给予四种不同剂量的乳香属粉末给三硝基苯磺酸诱导的结肠炎大鼠口服。84 只雄性 Wistar 大鼠随机分为七组：A，对照组；B，结肠炎；C-F，结肠炎大鼠每天补充乳香属粉末，剂量分别为（C）50mg/kg、（D）100mg/kg、（E）200mg/kg 和（F）300mg/kg 体重；和 G，结肠炎大鼠每天用皮质醇（25μg/kg 体重）治疗。通过显微镜评估结肠损伤。在结肠标本中测量细胞因子肿瘤坏死因子-α、细胞间黏附分子-1（ICAM-1）、白细胞介素（IL）-6、IL-8 和 IL-10 以及丙二醛。结果表示为均数±SE 值。结肠炎的组织学改善（P≤.001）和结肠指数的显著差异在治疗 3 天后发生。每天给予 100mg/kg 体重的乳香属粉末降低了所有炎症细胞因子（P≤.05），而 50mg/kg 体重的乳香属粉末和皮质醇治疗仅降低了 ICAM-1（P≤.05 和 P≤.01）。所有治疗组的丙二醛均明显受到抑制（P≤.01）。IL-10 保持不变。治疗 6 天后细胞因子和丙二醛仍未改变。因此，乳香属粉末可能在治疗克罗恩病方面具有治疗作用，调节氧化应激/抗氧化平衡并调节炎症。
