Tono-oka T, Nakayama M, Gotohda E, Takeda T
Tohoku J Exp Med. 1979 Feb;127(2):161-7. doi: 10.1620/tjem.127.161.
Agents known to increase intracellular levels of cyclic 3', 5'-adenosine monophosphate (cyclic AMP) were examined for their effect on tissue factor generation by mononuclear cells cultured with E. coli endotoxin. Aminophylline, an inhibitor of phosphodiesterase, and epinephrine, a beta-adrenergic agent, showed an inhibitory effect, and these effects were reversible. Moreover, dibutyryl cyclic AMP also exhibited the effect. Dibutyryl cyclic GMP, however, did not enhance the tissue factor generation by mononuclear cells. On the basis of these observations, it was concluded that the phenomenon of tissue factor generation by mononuclear cells is a biological event, and that intracellular cyclic AMP has a possible role in modulating this phenomenon.
研究了已知可提高细胞内环磷酸3'，5'-腺苷（环磷腺苷）水平的药物对用大肠杆菌内毒素培养的单核细胞产生组织因子的影响。磷酸二酯酶抑制剂氨茶碱和β-肾上腺素能药物肾上腺素显示出抑制作用，且这些作用是可逆的。此外，二丁酰环磷腺苷也表现出该作用。然而，二丁酰环磷鸟苷并未增强单核细胞产生组织因子的作用。基于这些观察结果，得出结论：单核细胞产生组织因子的现象是一种生物学事件，且细胞内环磷腺苷可能在调节该现象中发挥作用。
