Chawapun N
Division of Therapeutic Radiology and Oncology, Faculty of Medicine, ChiangMai University, Chiang Mai, Thailand.
Biomed Imaging Interv J. 2006 Jan;2(1):e22. doi: 10.2349/biij.2.1.e22. Epub 2006 Jan 1.
Radiation therapy is an important local cytotoxic modality for cancer treatment whose aim is to control the disease while minimising damage to normal tissue. The combination of different treatment modalities offers a more effective cure and reduction in normal tissue toxicity. However, the differences in genetic profiles can cause diverse treatment outcomes. Multidisciplinary research, where technologies and knowledge from different areas are integrated, is necessary to design the optimal regimen for individualised cancer treatment. This paper offers an overview of some new cancer treatment strategies; the impact of molecular imaging on radiation oncology; and a computer simulation model to optimise treatment planning based on patient information. It briefly discusses molecular targeted therapy, tumour microenvironment and bioreductive agents, and evidence for making individualised medicine a reality. Using DNA microarrays and proteomic technologies, information on defined molecular targets and genetic profiling for individual patients can be obtained and new algorithms for radiation oncology-related diagnosis, treatment response and prognosis can be developed.
放射治疗是癌症治疗中一种重要的局部细胞毒性治疗方式，其目的是控制疾病，同时将对正常组织的损害降至最低。不同治疗方式的联合使用能更有效地治愈疾病并降低正常组织毒性。然而，基因谱的差异会导致不同的治疗结果。整合不同领域技术和知识的多学科研究对于设计个体化癌症治疗的最佳方案是必要的。本文概述了一些新的癌症治疗策略；分子成像对放射肿瘤学的影响；以及基于患者信息优化治疗计划的计算机模拟模型。它简要讨论了分子靶向治疗、肿瘤微环境和生物还原药物，以及实现个体化医疗的证据。使用DNA微阵列和蛋白质组学技术，可以获得个体患者特定分子靶点和基因谱的信息，并开发与放射肿瘤学相关的诊断、治疗反应和预后的新算法。
