Department of Radiation Oncology, University of Freiburg, Freiburg, Germany.
Int J Radiat Biol. 2010 Mar;86(3):252-9. doi: 10.3109/09553000903419320.
The 2nd Langendorff Congress in Freiburg in Breisgau (Germany) gathered basic and translational scientists as well as clinicians interested in recent developments in molecular and clinical radiobiology. The topics ranged from the most recent insight into the organisation of the DNA damage response and radiotherapeutically relevant cell death mechanisms to biological imaging for treatment planning and advances in the understanding of the molecular biological effects of particle beams. Clinical aspects of stem cell and tumour stem cell biology as well as of angiogenesis and hypoxia, the search for novel molecular radiosensitisers and potential strategies for exploitation of the immune system to further improve tumour radiotherapy were also discussed.
This report surveys the presentations at the meeting, considering their significance in light of the literature, and documents the increasing importance of molecular radiobiology for clinical radiooncology.
第二届弗莱堡朗根多夫（德国）分子与临床放射生物学研讨会聚集了基础和转化科学家以及对分子和临床放射生物学最新进展感兴趣的临床医生。会议的主题涵盖了从 DNA 损伤反应的最新认识和放射治疗相关细胞死亡机制到治疗计划的生物成像以及对粒子束分子生物学效应的理解的最新进展。会议还讨论了干细胞和肿瘤干细胞生物学、血管生成和缺氧、寻找新的分子放射增敏剂以及利用免疫系统的潜在策略以进一步提高肿瘤放射治疗的临床方面。
本报告调查了会议的演讲，根据文献考虑了它们的意义，并记录了分子放射生物学对临床肿瘤学的重要性日益增加。
