利用和调节炎症反应在骨再生策略中的作用。
Harnessing and modulating inflammation in strategies for bone regeneration.
机构信息
Department of Bioengineering, Rice University, Houston, Texas 77251-1892, USA.
出版信息
Tissue Eng Part B Rev. 2011 Dec;17(6):393-402. doi: 10.1089/ten.TEB.2011.0182. Epub 2011 Jun 30.
Abstract
Inflammation is an immediate response that plays a critical role in healing after fracture or injury to bone. However, in certain clinical contexts, such as in inflammatory diseases or in response to the implantation of a biomedical device, the inflammatory response may become chronic and result in destructive catabolic effects on the bone tissue. Since our previous review 3 years ago, which identified inflammatory signals critical for bone regeneration and described the inhibitory effects of anti-inflammatory agents on bone healing, a multitude of studies have been published exploring various aspects of this emerging field. In this review, we distinguish between regenerative and damaging inflammatory processes in bone, update our discussion of the effects of anti-inflammatory agents on bone healing, summarize recent in vitro and in vivo studies demonstrating how inflammation can be modulated to stimulate bone regeneration, and identify key future directions in the field.
摘要
炎症反应是骨折或骨损伤后愈合过程中的一种重要的即时反应。然而，在某些临床情况下，如炎症性疾病或生物医学设备植入后，炎症反应可能会变成慢性，并对骨组织产生破坏性的分解代谢作用。自我们 3 年前的上一次综述以来，已经发表了许多研究探索这个新兴领域的各个方面，该综述确定了对骨再生至关重要的炎症信号，并描述了抗炎药物对骨愈合的抑制作用。在这篇综述中，我们区分了骨内的再生性和破坏性炎症过程，更新了我们对抗炎药物对骨愈合影响的讨论，总结了最近的体外和体内研究，这些研究表明如何调节炎症以刺激骨再生，并确定该领域的关键未来方向。
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