调节炎症反应以促进骨组织再生。
Modulation of the inflammatory response for enhanced bone tissue regeneration.
作者信息
Mountziaris Paschalia M, Mikos Antonios G
机构信息
Department of Bioengineering, Rice University, Houston, Texas 77251-1892, USA.
出版信息
Tissue Eng Part B Rev. 2008 Jun;14(2):179-86. doi: 10.1089/ten.teb.2008.0038.
Abstract
Proinflammatory cytokines are infamous for their catabolic effects on tissues and joints in both inflammatory diseases and following the implantation of biomedical devices. However, recent studies indicate that many of these same molecules are critical for triggering tissue regeneration following injury. This review will discuss the role of inflammatory signals in regulating bone regeneration and the impact of both immunomodulatory and antiinflammatory pharmacologic agents on fracture healing, to demonstrate the importance of incorporating rational control of inflammation into the design of tissue engineering strategies.
摘要
促炎细胞因子因其在炎症性疾病以及生物医学装置植入后对组织和关节的分解代谢作用而声名狼藉。然而，最近的研究表明，许多这些相同的分子对于损伤后触发组织再生至关重要。本综述将讨论炎症信号在调节骨再生中的作用以及免疫调节和抗炎药物对骨折愈合的影响，以证明在组织工程策略设计中纳入合理炎症控制的重要性。
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