Texas Health Physicians Group, Orthopedic Medicine Specialists, Arlington, TX, USA.
J Orthop Trauma. 2012 Dec;26(12):708-11. doi: 10.1097/BOT.0b013e318274da8b.
Bone healing after fracture occurs in a well-organized manner and involves a multitude of cell types, inflammatory cytokines, growth factors, prostaglandins, and certain vitamins. Some of the means by which alterations in these essential components affect bone repair are understood, whereas others still need to be delineated. Based on clinical experience and basic science research, certain clinical conditions have become associated with delays in bone repair after fracture. These conditions include chronic inflammation, diabetes, hypovitaminosis, aging, and polytrauma. This brief report reviews some of the ways by which these conditions have been shown to negatively influence bone repair.
骨折后骨愈合是一个有序的过程，涉及多种细胞类型、炎症细胞因子、生长因子、前列腺素和某些维生素。人们已经了解了这些重要成分的变化如何影响骨修复的一些方式，而其他方式仍有待阐明。基于临床经验和基础科学研究，某些临床情况与骨折后骨修复延迟有关。这些情况包括慢性炎症、糖尿病、维生素缺乏症、衰老和多发伤。本简要报告回顾了这些情况显示如何对骨修复产生负面影响的一些方式。
