Heal thyself: using endogenous regeneration to repair bone.

Bone has the capacity to repair itself after an injury, and this occurs in normal fracture repair. This reparative process can be harnessed to regenerate segments of bone using distraction osteogenesis, in which the healing bone is slowly stretched. The use of animal models is identifying the important sources of cells for this endogenous bone regeneration, signaling molecules that regulate this reparative process, and the environmental cues important for success bone regeneration. A more complete understanding of the cells and pathways involved in this process can be applied to improve the outcome of distraction osteogenesis and to the development of methods to enhance endogenous bone regeneration.