Division of Orthopaedics and Department of Surgery, University of Toronto, Ontario, Canada.
Tissue Eng Part B Rev. 2011 Dec;17(6):431-6. doi: 10.1089/ten.TEB.2011.0189. Epub 2011 Oct 12.
Bone has the capacity to repair itself after an injury, and this occurs in normal fracture repair. This reparative process can be harnessed to regenerate segments of bone using distraction osteogenesis, in which the healing bone is slowly stretched. The use of animal models is identifying the important sources of cells for this endogenous bone regeneration, signaling molecules that regulate this reparative process, and the environmental cues important for success bone regeneration. A more complete understanding of the cells and pathways involved in this process can be applied to improve the outcome of distraction osteogenesis and to the development of methods to enhance endogenous bone regeneration.
骨骼在受伤后有自我修复的能力，这在正常的骨折修复中发生。可以利用牵张成骨术来利用这种修复过程来再生骨段，在该过程中，愈合的骨骼会缓慢拉伸。使用动物模型可以确定用于这种内源性骨再生的重要细胞来源、调节这种修复过程的信号分子，以及对于成功骨再生重要的环境线索。对这一过程中涉及的细胞和途径有更全面的了解，可以应用于改善牵张成骨术的效果，并开发增强内源性骨再生的方法。
