成人过敏性紫癜的临床意义。

Jithpratuck Warit, Elshenawy Yasmin, Saleh Hana, Youngberg George, Chi David S, Krishnaswamy Guha

Departments of Internal Medicine, Quillen College of Medicine, East Tennessee State University, TN, USA.

Clin Mol Allergy. 2011 May 27;9(1):9. doi: 10.1186/1476-7961-9-9.

Henoch-Schonlein Purpura (HSP) is a small vessel vasculitis mediated by IgA-immune complex deposition. It is characterized by the clinical tetrad of non-thrombocytopenic palpable purpura, abdominal pain, arthritis and renal involvement. Pathologically, it can be considered a form of immune complex-mediated leukocytoclastic vasculitis (LCV) involving the skin and other organs. Though it primarily affects children (over 90% of cases), the occurrence in adults has been rarely reported. Management often involves the use of immunomodulatory or immune-suppressive regimens.

过敏性紫癜（HSP）是一种由IgA免疫复合物沉积介导的小血管炎。其特征为非血小板减少性可触性紫癜、腹痛、关节炎和肾脏受累这一临床四联征。病理上，它可被视为一种涉及皮肤和其他器官的免疫复合物介导的白细胞破碎性血管炎（LCV）形式。尽管它主要影响儿童（超过90%的病例），但成人发病的情况鲜有报道。治疗通常涉及使用免疫调节或免疫抑制方案。