Department of Surgery, Nihon University School of Medicine, Tokyo, Japan.
Ann Thorac Surg. 2011 Jun;91(6):e83-4. doi: 10.1016/j.athoracsur.2011.01.038.
A 20-year-old woman with recurrent right pneumothorax was admitted to our hospital. A thoracoscopic bullectomy and lung biopsy was performed under general anesthesia. According to the histopathologic findings of permanent sections, a tissue specimen of diffuse lung disease revealed eosinophil infiltration and the presence of fibroblasts. Immunohistochemical stain showed S-100 protein-positive, as well as cluster of differentiation-68-positive large Langerhans cells. As a result, pulmonary Langerhans cell histiocytosis was diagnosed. The patient had an uncomplicated postoperative course and was discharged from the hospital on postoperative day 5. No recurrence was observed during the 6-month observation period.
一位 20 岁的年轻女性因反复发作的右侧气胸被收入我院。在全身麻醉下进行了胸腔镜肺大疱切除术和肺活检。根据永久切片的组织病理学发现，弥漫性肺疾病的组织标本显示嗜酸性粒细胞浸润和成纤维细胞存在。免疫组化染色显示 S-100 蛋白阳性，以及 CD68 阳性的大型朗格汉斯细胞簇。因此，诊断为肺朗格汉斯细胞组织细胞增生症。患者术后恢复顺利，术后第 5 天出院。在 6 个月的观察期内未观察到复发。
