Kreider J W, Patrick S D, Cladel N M, Welsh P A
Department of Pathology, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey.
Virology. 1990 Jul;177(1):415-7. doi: 10.1016/0042-6822(90)90503-j.
Warts of the hands and feet are common cutaneous diseases. Human papillomaviruses types 1 and 2 are probably responsible for most of the lesions. It is difficult to study these infections in the laboratory, since human papillomaviruses do not replicate in cell cultures or experimental animals. We have recently developed a system in which xenografts of human tissues were infected with HPV-11 and transplanted beneath the renal capsule of athymic mice. We now report the adaptation of this system to the induction of HPV-1 infection of xenografts of fetal human foot and hand skin. The experimentally produced warts have the same morphology as naturally occurring lesions. HPV-1 DNA and papillomavirus capsid antigen are abundant in the experimentally infected tissues.
手足疣是常见的皮肤疾病。1型和2型人乳头瘤病毒可能是导致大多数此类病变的原因。由于人乳头瘤病毒无法在细胞培养物或实验动物中复制，因此在实验室中研究这些感染颇具难度。我们最近开发了一种系统，在该系统中，人组织异种移植物被HPV - 11感染，并移植到无胸腺小鼠的肾包膜下方。我们现在报告该系统适用于诱导人胎儿手足皮肤异种移植物发生HPV - 1感染。实验产生的疣与自然发生的病变具有相同的形态。在实验感染的组织中，HPV - 1 DNA和乳头瘤病毒衣壳抗原含量丰富。
