Tsunoda A, Talbot I C, Nicholls R J
St Mark's Hospital, London, UK.
Br J Surg. 1990 May;77(5):506-8. doi: 10.1002/bjs.1800770510.
The incidence of dysplasia in the mucosal strippings from the anorectal stump was studied in 132 patients treated by restorative proctocolectomy with ileal reservoir for ulcerative colitis and familial adenomatosis. The anorectal mucosa was stripped from the level of division of the gut tube to the dentate line. Of 118 patients with ulcerative colitis, 12 (10.2 per cent) had dysplasia in some part of the large bowel. Mucosal strippings were examined histologically in 118 cases, of which only three (2.5 per cent) showed dysplasia. There was a correlation between dysplasia and the presence of carcinoma and the duration of the disease in the operative specimen of colon and rectum and also in the anorectal mucosal specimen although the number of patients with carcinoma (eight cases) in this analysis was small. All 14 patients with familial adenomatous polyposis showed large bowel mucosal dysplasia in the operative specimen which was severe in six cases. Anorectal mucosal strippings were examined in these patients and 12 showed dysplasia which was severe in three.
对132例因溃疡性结肠炎和家族性腺瘤病接受保留回肠储袋的直肠结肠切除术治疗的患者，研究了其直肠肛管残端黏膜剥脱术中发育异常的发生率。将直肠肛管黏膜从肠管切断处至齿状线进行剥脱。在118例溃疡性结肠炎患者中，12例（10.2%）在大肠的某些部位出现发育异常。对118例患者的黏膜剥脱组织进行了组织学检查，其中仅3例（2.5%）显示发育异常。发育异常与结肠和直肠手术标本以及直肠肛管黏膜标本中的癌的存在和疾病持续时间之间存在相关性，尽管在此分析中患癌患者数量（8例）较少。所有14例家族性腺瘤性息肉病患者在手术标本中均显示大肠黏膜发育异常，其中6例严重。对这些患者的直肠肛管黏膜剥脱组织进行了检查，12例显示发育异常，其中3例严重。
