Lefkowitz C A, Mildenberger R R, Liu P, Kimball B P, Mickleborough L, Weisel R, Houle S, McLaughlin P R
Division of Cardiology, Toronto General Hospital, University of Toronto, Ontario, Canada.
Eur Heart J. 1990 May;11(5):403-12. doi: 10.1093/oxfordjournals.eurheartj.a059723.
We evaluated the accuracy of the non-imaging nuclear probe for measuring various parameters of left ventricular function by comparing these with simultaneous measurements acquired via tantalum marker cine-fluoroscopy. Eight patients with surgically implanted mid-myocardial tantalum markers were studied during cardiac catheterization. High temporal resolution tantalum marker-derived volume/time curves were generated and calibrated to absolute endocardial volumes by comparison with contrast left ventricular angiography. Left ventricular function parameters were acquired at baseline and during atrial pacing, nitroprusside infusion and volume loading. Simultaneous measurements obtained with the nuclear probe and via tantalum marker cine-fluoroscopy were compared. The following correlation coefficients were obtained: ejection fraction, r = 0.49, P less than 0.001; peak ejection rate, r = 0.41, P less than 0.01; mean ejection rate, r = 0.62, P less than 0.001; time to peak ejection, r = 0.73, P less than 0.001; peak filling rate, r = 0.73, P less than 0.001; time to peak filling, r = 0.58, P less than 0.001. Relative changes in end-diastolic volume were accurately tracked by the nuclear probe in six of seven patients (r values 0.77-0.93). These results suggest that measurements of certain left ventricular volume parameters with the nuclear probe may not accurately reflect true volume changes as measured by tantalum marker cine-fluoroscopy. Although, the probe may be useful in tracking relative changes in end-diastolic volume, we would advise caution in using this instrument for studies requiring accurate measurements of ejection and filling parameters.
我们通过将非成像核探头测量左心室功能的各种参数与通过钽标记电影荧光透视法同时获得的测量结果进行比较，评估了该探头的准确性。在心脏导管插入术期间，对8例手术植入心肌中部钽标记的患者进行了研究。生成了高时间分辨率的钽标记衍生的容积/时间曲线，并通过与对比剂左心室血管造影进行比较，将其校准为绝对心内膜容积。在基线以及心房起搏、硝普钠输注和容量负荷期间获取左心室功能参数。比较了用核探头和通过钽标记电影荧光透视法同时获得的测量结果。得到了以下相关系数：射血分数，r = 0.49，P < 0.001；峰值射血率，r = 0.41，P < 0.01；平均射血率，r = 0.62，P < 0.001；射血达峰时间，r = 0.73，P < 0.001；峰值充盈率，r = 0.73，P < 0.001；充盈达峰时间，r = 0.58，P < 0.001。7例患者中有6例，核探头准确跟踪了舒张末期容积的相对变化（r值为0.77 - 0.93）。这些结果表明，用核探头测量某些左心室容积参数可能无法准确反映钽标记电影荧光透视法所测量的真实容积变化。虽然该探头可能有助于跟踪舒张末期容积的相对变化，但对于需要准确测量射血和充盈参数的研究，我们建议谨慎使用该仪器。
