Shanghai Institute of Ceramics, Chinese Academy of Sciences, China.
Aust Dent J. 2011 Jun;56(2):175-80. doi: 10.1111/j.1834-7819.2011.01321.x.
The aim of this study was to evaluate the dentinal tubule occluding ability of tricalcium silicate (Ca(3) SiO(5) or C(3) S) in vitro.
Dentine discs were prepared from extracted caries-free human third molars and etched with 0.02 M citric acid (pH 4) for 3 minutes in order to produce patent dentinal tubules. Tricalcium silicate pastes of different viscosities were applied to the surface of the dentine specimens for 3 minutes and then removed with a swab followed by deionized water rinse. The dentine specimens were immersed in artificial saliva for 7 days. The tubule occlusion, sealing depth and chemical composition of the dentine specimens and bonding force between the dentine matrix and mineralized layer were evaluated by scanning electron microscopy, energy dispersion X-ray spectroscopy, X-ray diffraction analysis and a nanoscratch test.
A homogeneous layer of mineral crystals was precipitated onto the dentine surface and caused significant occlusion of the dentinal tubules. The dentine permeability and sealing depth of the C(3) S increased with the decrease of viscosity of the paste. With a proper viscosity of C(3) S pastes, the interface between the mineralized layer and the dentine matrix bonded well.
This study suggests that C(3) S may be an effective agent for the treatment of dentine hypersensitivity.
本研究旨在评估硅酸三钙(Ca(3)SiO(5)或 C(3)S)在体外封闭牙本质小管的能力。
从无龋的人第三磨牙中制备牙本质圆盘,并使用 0.02 M 柠檬酸(pH 4)蚀刻 3 分钟,以产生明显的牙本质小管。将不同粘度的硅酸三钙糊剂涂在牙本质标本表面 3 分钟,然后用棉签去除,再用去离子水冲洗。将牙本质标本浸泡在人工唾液中 7 天。通过扫描电子显微镜、能量色散 X 射线能谱、X 射线衍射分析和纳米划痕试验评估牙本质标本的小管封闭、密封深度和化学组成以及牙本质基质与矿化层之间的粘结力。
在牙本质表面沉淀出一层均匀的矿物质晶体,导致牙本质小管显著封闭。C(3)S 的牙本质渗透性和密封深度随糊剂粘度的降低而增加。适当粘度的 C(3)S 糊剂可使矿化层与牙本质基质之间的界面结合良好。
本研究表明,C(3)S 可能是治疗牙本质过敏的有效药物。