Zhong Y, Liu J, Li X, Yin W, He T, Hu D, Liao Y, Yao X, Wang Y
State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China; Department of Preventive Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
Aust Dent J. 2015 Mar;60(1):96-103. doi: 10.1111/adj.12241.
This in vitro study aimed to assess the ability and efficacy of HX-BGC, a novel bioactive glass-ceramic (SiO2-P2 O5-CaO-Na2 O-SrO), to reduce dentine tubule permeability.
Dentine discs from human third molars were etched and randomly allocated into five groups: Group 1--distilled water; Group 2--Sensodyne Repair toothpaste (containing NovaMin®); Group 3--HX-BGC toothpaste (containing 7.5% HX-BGC); Group 4--control toothpaste (without HX-BGC); and Group 5--HX-BGC powder. Specimens were treated daily by brushing with an electric toothbrush for 20 seconds. Between daily treatments (7 days total), specimens were immersed in artificial saliva for 24 hours. Dentine permeability was measured at baseline, after the first treatment, after the first 24-hour immersion in artificial saliva and at the end of day 7. Dentine morphology and surface deposits were observed by scanning electron microscopy after one day and 7 days of treatment, respectively.
Sensodyne Repair and bioactive glass-ceramic toothpaste significantly and immediately lowered dentine permeability. The HX-BGC powder group showed the highest reduction in dentine permeability after 7 days of treatment.
The novel bioactive glass-ceramic material HX-BGC is effective in reducing dentine permeability by occluding open dentine tubules, indicating that HX-BGC may be a potential treatment for dentine hypersensitivity.
本体外研究旨在评估新型生物活性玻璃陶瓷（SiO₂-P₂O₅-CaO-Na₂O-SrO）HX-BGC降低牙本质小管通透性的能力和效果。
将人第三磨牙的牙本质盘进行酸蚀，并随机分为五组：第1组——蒸馏水；第2组——舒适达修复牙膏（含诺华敏®）；第3组——HX-BGC牙膏（含7.5% HX-BGC）；第4组——对照牙膏（不含HX-BGC）；第5组——HX-BGC粉末。每天用电动牙刷刷牙20秒对标本进行处理。在每日处理期间（共7天），将标本浸泡在人工唾液中24小时。在基线、首次处理后、首次浸泡在人工唾液24小时后以及第7天结束时测量牙本质通透性。分别在处理1天和7天后通过扫描电子显微镜观察牙本质形态和表面沉积物。
舒适达修复牙膏和生物活性玻璃陶瓷牙膏能显著且立即降低牙本质通透性。HX-BGC粉末组在处理7天后牙本质通透性降低幅度最大。
新型生物活性玻璃陶瓷材料HX-BGC通过封闭开放的牙本质小管有效降低牙本质通透性，表明HX-BGC可能是治疗牙本质过敏的一种潜在方法。
