一种新型含草酸钾的牙齿脱敏漱口水：一项体外对比研究。

A novel potassium oxalate-containing tooth-desensitising mouthrinse: a comparative in vitro study.

作者信息

Sharma Deepak, Hong Christopher X, Heipp Paul S

机构信息

Oral Care Research and Development, Johnson & Johnson Consumer & Personal Products Worldwide, Skillman, NJ 08558, USA.

出版信息

J Dent. 2013 Jul;41 Suppl 4:S18-27. doi: 10.1016/S0300-5712(13)70003-4.

DOI:10.1016/S0300-5712(13)70003-4

PMID:23929641

Abstract

OBJECTIVE

To compare the efficacy of a new potassium oxalate (KO)-containing mouthrinse [Listerine® Advanced Defence Sensitive (LADS)] in reducing dentine permeability and occluding open dentinal tubules versus other desensitising products.

METHODS

The permeability of acid-etched dentine disks was measured by hydraulic conductance; dentine surfaces were examined by scanning electron microscopy and energy-dispersive X-ray spectroscopy. The KO concentration was optimised for tubule occlusion by screening formulations containing 0.0-2.0% KO (n=5 disks per concentration). The optimal formulation was compared with five commercial products with non-oxalate occlusion technologies. After establishing the baseline permeability of acid-etched dentine disks, disks (n=6 per product) were randomly treated with the desensitising products (12 treatments, each 60 s, alternated with distilled-water rinses) and permeability was measured at intervals. Occluded disks were acid challenged. All experiments were conducted at room temperature. An unpooled, two-tailed t test was performed to assess between-treatment differences in relative residual permeability.

RESULTS

The optimal concentration of KO in LADS was 1.4%, which provided ≈ 100% reduction in dentine permeability after nine treatments. Only LADS reduced permeability to zero and was significantly more effective in reducing dentine permeability than the other products (p ≤ 0.033 vs all other test products). All products partially occluded dentine. The occlusion associated with LADS was substantially more stable in resisting acid challenge versus Colgate® Sensitive Pro-Relief mouthrinse (p=0.054) and significantly more stable versus all other test products (p ≤ 0.045), as determined by dentine permeability.

CONCLUSION

LADS was significantly more effective in occluding open dentinal tubules versus other desensitising products.

CLINICAL SIGNIFICANCE

LADS provides fast, complete and stable intratubular occlusion of patent dentinal tubules.

摘要

目的

比较一种含新型草酸钾（KO）的漱口水[李施德林®高级防护敏感型（LADS）]与其他脱敏产品在降低牙本质渗透性和封闭开放牙本质小管方面的疗效。

方法

通过液压传导率测量酸蚀牙本质盘的渗透性；通过扫描电子显微镜和能量色散X射线光谱仪检查牙本质表面。通过筛选含0.0 - 2.0% KO的配方（每个浓度n = 5个牙本质盘）来优化KO浓度以实现小管封闭。将最佳配方与五种采用非草酸盐封闭技术的市售产品进行比较。在确定酸蚀牙本质盘的基线渗透性后，将牙本质盘（每种产品n = 6个）随机用脱敏产品处理（12次处理，每次60秒，与蒸馏水冲洗交替进行），并定期测量渗透性。对封闭的牙本质盘进行酸刺激。所有实验均在室温下进行。进行非合并的双尾t检验以评估处理间相对残余渗透性的差异。

结果

LADS中KO的最佳浓度为1.4%，经过九次处理后牙本质渗透性降低约100%。只有LADS能将渗透性降低至零，并且在降低牙本质渗透性方面比其他产品显著更有效（与所有其他测试产品相比，p≤0.033）。所有产品都能部分封闭牙本质。根据牙本质渗透性测定，与高露洁®敏感专业舒缓漱口水相比，LADS相关的封闭在抵抗酸刺激方面显著更稳定（p = 0.054），与所有其他测试产品相比显著更稳定（p≤0.045）。