Xie Wei, Qiu Penghe, Mao Chuanbin
Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, University of Oklahoma, 101 Stephenson Parkway, Norman, OK, 73019, USA.
J Mater Chem. 2011 Apr 14;21(14):5190-5202. doi: 10.1039/C0JM03301D.
Surface-enhanced Raman scattering (SERS) is a phenomenon that occurs on nanoscale-roughed metallic surface. The magnitude of the Raman scattering signal can be greatly enhanced when the scatterer is placed in the very close vicinity of the surface, which enables this phenomenon to be a highly sensitive analytical technique. SERS inherits the general strongpoint of conventional Raman spectroscopy and overcomes the inherently small cross section problem of a Raman scattering. It is a sensitive and nondestructive spectroscopic method for biological samples, and can be exploited either for the delivery of molecular structural information or for the detection of trace levels of analytes. Therefore, SERS has long been regarded as a powerful tool in biomedical research. Metallic nanostructure plays a key role in all the biomedical applications of SERS because the enhanced Raman signal can only be obtained on the surface of a finely divided substrate. This review focuses on progress made in the use of SERS as an analytical technique in bio-imaging, analysis and detection. Recent progress in the fabrication of SERS active nanostructures is also highlighted.
表面增强拉曼散射（SERS）是一种发生在纳米级粗糙金属表面的现象。当散射体置于非常靠近表面的位置时，拉曼散射信号的强度会大大增强，这使得该现象成为一种高灵敏度的分析技术。SERS继承了传统拉曼光谱的一般优点，并克服了拉曼散射固有的小截面问题。它是一种用于生物样品的灵敏且无损的光谱方法，可用于提供分子结构信息或检测痕量分析物。因此，SERS长期以来一直被视为生物医学研究中的一种强大工具。金属纳米结构在SERS的所有生物医学应用中起着关键作用，因为增强的拉曼信号只能在细分的基底表面获得。本文综述聚焦于SERS作为一种分析技术在生物成像、分析和检测方面取得的进展。还重点介绍了SERS活性纳米结构制备方面的最新进展。
