State Key Laboratory of Mechanical System and Vibration, Shanghai Jiao Tong University, Shanghai 200240, P.R. China.
Department of Instrument Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, P.R. China.
Sci Rep. 2017 Jan 4;7:39814. doi: 10.1038/srep39814.
Surface-enhanced Raman spectroscopy (SERS) has been a powerful tool for applications including single molecule detection, analytical chemistry, electrochemistry, medical diagnostics and bio-sensing. Especially, flexible SERS substrates are highly desirable for daily-life applications, such as real-time and in situ Raman detection of chemical and biological targets, which can be used onto irregular surfaces. However, it is still a major challenge to fabricate the flexible SERS substrate on large-area substrates using a facile and cost-effective technique. The roll-to-roll ultraviolet nanoimprint lithography (R2R UV-NIL) technique provides a solution for the continuous fabrication of flexible SERS substrate due to its high-speed, large-area, high-resolution and high-throughput. In this paper, we presented a facile and cost-effective method to fabricate flexible SERS substrate including the fabrication of polymer nanostructure arrays and the metallization of the polymer nanostructure arrays. The polymer nanostructure arrays were obtained by using R2R UV-NIL technique and anodic aluminum oxide (AAO) mold. The functional SERS substrates were then obtained with Au sputtering on the surface of the polymer nanostructure arrays. The obtained SERS substrates exhibit excellent SERS and flexibility performance. This research can provide a beneficial direction for the continuous production of the flexible SERS substrates.
表面增强拉曼光谱（SERS）已成为一种强大的工具，可应用于包括单分子检测、分析化学、电化学、医学诊断和生物传感等领域。特别是，柔性 SERS 基底对于日常生活中的应用非常理想，例如对化学和生物目标的实时和原位拉曼检测，可以应用于不规则表面。然而，使用简单且具有成本效益的技术在大面积基底上制造柔性 SERS 基底仍然是一个重大挑战。卷对卷紫外纳米压印光刻（R2R UV-NIL）技术由于其高速、大面积、高分辨率和高吞吐量，为柔性 SERS 基底的连续制造提供了一种解决方案。在本文中，我们提出了一种简单且具有成本效益的方法来制造柔性 SERS 基底，包括聚合物纳米结构阵列的制造和聚合物纳米结构阵列的金属化。通过使用 R2R UV-NIL 技术和阳极氧化铝（AAO）模具获得聚合物纳米结构阵列。然后通过在聚合物纳米结构阵列表面溅射 Au 获得功能性 SERS 基底。所获得的 SERS 基底表现出优异的 SERS 和柔韧性性能。这项研究可为柔性 SERS 基底的连续生产提供有益的方向。
