DKMS German Bone Marrow Donor Center, Tübingen, Germany.
PLoS One. 2011;6(5):e20268. doi: 10.1371/journal.pone.0020268. Epub 2011 May 20.
Large registries of potential unrelated stem cell donors have been established in order to enable stem cell transplantation for patients without HLA-identical related donors. Donor search is complicated by the fact that the stored HLA information of many registered donors is incomplete. We carried out a project that was aimed to improve chances of patients with ongoing donor searches to find an HLA-matched unrelated donor. For that purpose, we carried out additional donor center-initiated HLA-DRB1 typing of donors who were only typed for the HLA loci A and B so far and were potential matches for patients in need of a stem cell transplant. In total, 8,861 donors were contacted for donor center-initiated HLA-DRB1 typing within 1,089 donor searches. 12 of these donors have donated stem cells so far, 8 thereof for their respective target patients. We conclude that chances of patients with ongoing donor searches to find an HLA-matched unrelated donor can indeed be improved by donor-center initiated typing that is carried out in addition to the standard donor search process. Our results also raise questions regarding the appropriate use of incompletely typed donors within unrelated donor searches.
为了能够为没有 HLA 完全匹配的相关供者的患者进行干细胞移植，已经建立了大型的潜在非亲缘供者干细胞库。由于存储的许多已登记供者的 HLA 信息不完整，供者搜索变得复杂。我们开展了一个项目，旨在提高正在进行供者搜索的患者找到 HLA 匹配的非亲缘供者的机会。为此，我们对迄今为止仅对 HLA 位点 A 和 B 进行了分型且对需要干细胞移植的患者可能是匹配供者的供者进行了额外的供者中心发起的 HLA-DRB1 分型。在 1,089 次供者搜索中，总共联系了 8,861 名供者进行供者中心发起的 HLA-DRB1 分型。到目前为止，其中 12 名供者已经捐献了干细胞，其中 8 名供者为各自的目标患者捐献了干细胞。我们得出结论，通过在标准供者搜索过程之外进行供者中心发起的分型，可以确实提高正在进行供者搜索的患者找到 HLA 匹配的非亲缘供者的机会。我们的结果还提出了有关在非亲缘供者搜索中如何适当使用不完全分型供者的问题。
