Sutherland Calum
Biomedical Research Institute, University of Dundee, Dundee DD1 9SY, UK.
Int J Alzheimers Dis. 2011;2011:505607. doi: 10.4061/2011/505607. Epub 2011 May 18.
Nearly 100 proteins are proposed to be substrates for GSK3, suggesting that this enzyme is a fundamental regulator of almost every process in the cell, in every tissue in the body. However, it is not certain how many of these proposed substrates are regulated by GSK3 in vivo. Clearly, the identification of the physiological functions of GSK3 will be greatly aided by the identification of its bona fide substrates, and the development of GSK3 as a therapeutic target will be highly influenced by this range of actions, hence the need to accurately establish true GSK3 substrates in cells. In this paper the evidence that proposed GSK3 substrates are likely to be physiological targets is assessed, highlighting the key cellular processes that could be modulated by GSK3 activity and inhibition.
近100种蛋白质被认为是糖原合成酶激酶3（GSK3）的底物，这表明该酶是体内每个组织中细胞几乎所有过程的基本调节因子。然而，目前尚不确定这些被认为的底物中有多少在体内受GSK3调节。显然，确定GSK3的真实底物将极大地有助于确定其生理功能，而GSK3作为治疗靶点的开发将受到其作用范围的高度影响，因此需要在细胞中准确确定真正的GSK3底物。本文评估了所提出的GSK3底物可能是生理靶点的证据，突出了可能受GSK3活性和抑制作用调节的关键细胞过程。
