Clark Andrew G, Paluch Ewa
Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany.
Results Probl Cell Differ. 2011;53:31-73. doi: 10.1007/978-3-642-19065-0_3.
Many cell types undergo dramatic changes in shape throughout the cell cycle. For individual cells, a tight control of cell shape is crucial during cell division, but also in interphase, for example during cell migration. Moreover, cell cycle-related cell shape changes have been shown to be important for tissue morphogenesis in a number of developmental contexts. Cell shape is the physical result of cellular mechanical properties and of the forces exerted on the cell. An understanding of the causes and repercussions of cell shape changes thus requires knowledge of both the molecular regulation of cellular mechanics and how specific changes in cell mechanics in turn effect global shape changes. In this chapter, we provide an overview of the current knowledge on the control of cell morphology, both in terms of general cell mechanics and specifically during the cell cycle.
许多细胞类型在整个细胞周期中会经历显著的形态变化。对于单个细胞而言，严格控制细胞形态在细胞分裂过程中至关重要，在间期也是如此，例如在细胞迁移过程中。此外，在许多发育背景下，与细胞周期相关的细胞形态变化已被证明对组织形态发生很重要。细胞形态是细胞力学特性以及施加在细胞上的力的物理结果。因此，要理解细胞形态变化的原因和影响，就需要了解细胞力学的分子调控以及细胞力学的特定变化如何反过来影响整体形态变化。在本章中，我们将概述当前关于细胞形态控制的知识，包括一般细胞力学方面以及细胞周期期间的具体情况。
