类风湿关节炎相关严重血管炎患者循环抗中性粒细胞胞浆抗体（ANCA）阴性。

Absence of circulating antineutrophil cytoplasm antibodies (ANCA) in severe vasculitis associated with rheumatoid arthritis.

作者信息

Nässberger L, Sjöholm A G, Sturfelt G

机构信息

Department of Medical Microbiology, University of Lund, Sweden.

出版信息

Scand J Rheumatol. 1990;19(3):189-92. doi: 10.3109/03009749009095042.

DOI:10.3109/03009749009095042

PMID:2163098

Abstract

Sixteen patients with classical rheumatoid arthritis (RA) complicated by severe vasculitis were studied and compared with a matched control group of 17 RA patients without vasculitis. A control group of 24 patients with unrelated disease was also included. Neither antineutrophil cytoplasmic antibodies (C-ANCA) nor anti-myeloperoxidase (anti-MPO) were found. Granulocyte specific antinuclear antibodies ("GS-ANA") were found in a higher frequency in the vasculitis group (75%) than in the RA control group (41%), but the difference was not statistically significant. No patient in the control group without RA had "GS-ANA".

摘要

对16例合并严重血管炎的典型类风湿关节炎（RA）患者进行了研究，并与17例无血管炎的配对RA患者对照组进行比较。还纳入了24例患有无关疾病的患者作为对照组。未发现抗中性粒细胞胞浆抗体（C-ANCA）和抗髓过氧化物酶（抗MPO）。血管炎组中粒细胞特异性抗核抗体（“GS-ANA”）的出现频率（75%）高于RA对照组（41%），但差异无统计学意义。无RA的对照组中没有患者出现“GS-ANA”。