Department of Pathology and Laboratory Medicine and Center for Cancer Research, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA.
J Interferon Cytokine Res. 2011 Jul;31(7):553-9. doi: 10.1089/jir.2011.0028. Epub 2011 Jun 1.
The nuclear factor κB (NF-κB) transcription factor regulates the expression of genes involved in cell survival and immune responses. We have identified a novel interferon (IFN)-activated signaling pathway that leads to NF-κB activation and demonstrate that a subset of IFN-stimulated genes and microRNAs that play key roles in cellular response to IFN is regulated by NF-κB. This review focuses on the IFN-induced NF-κB activation pathway and the role of NF-κB in the expression of IFN-induced coding and noncoding genes, antiviral activity and apoptosis, and the therapeutic application of IFN in cancer and infectious disease.
核因子 κB（NF-κB）转录因子调节参与细胞存活和免疫反应的基因的表达。我们已经确定了一种新的干扰素（IFN）激活信号通路，该通路导致 NF-κB 的激活，并证明了 IFN 刺激的基因和 microRNA 的亚组在细胞对 IFN 的反应中发挥关键作用，受 NF-κB 调控。这篇综述重点介绍了 IFN 诱导的 NF-κB 激活途径以及 NF-κB 在 IFN 诱导的编码和非编码基因表达、抗病毒活性和细胞凋亡中的作用，以及 IFN 在癌症和传染病中的治疗应用。
