Bursian A V, Timofeeva O P
Zh Evol Biokhim Fiziol. 1990 Jan-Feb;26(1):92-7.
At the 1st, 2nd and 3rd days after birth, subcutaneous injections of 6-oxydopamine in physiological solution containing 0.1% of ascorbic acid have been made to rat puppies in a dose 100 mg/kg per one injection. Within first three weeks, electromyographic studies were made on outbursts of autogenic periodic motor activity which is typical of animals at this age. It was shown that at the 3rd day of postnatal life, after 6-oxydopamine administration, total duration of motor excitation is significantly lower, whereas mean duration of the outbursts of continuous activity is lower even at the 7th day. Beginning from the 10th day, these parameters undergo opposite changes at the background of the increase in the number of outbursts and the decrease of intervals between the latter. The data obtained are discussed in relation to the role of catecholaminergic systems in regulation and realization of age dynamics of autogenic motor activity.
在出生后的第1天、第2天和第3天，给新生大鼠皮下注射溶于含0.1%抗坏血酸的生理溶液中的6-羟多巴胺，每次注射剂量为100mg/kg。在前三周内，对这种年龄的动物所特有的自发性周期性运动活动爆发进行了肌电图研究。结果表明，在出生后第3天，给予6-羟多巴胺后，运动兴奋的总持续时间显著降低，而即使在第7天，持续活动爆发的平均持续时间也较低。从第10天开始，在爆发次数增加和爆发间隔时间缩短的背景下，这些参数发生相反的变化。结合儿茶酚胺能系统在调节和实现自发性运动活动年龄动态中的作用，对所得数据进行了讨论。
