Timofeeva O P
Zh Evol Biokhim Fiziol. 1989 Jan-Feb;25(1):123-5.
In experiments on 3-day rat puppies, studies have been made of the effect of a stimulator of noradrenaline receptors--clonidine, and a stimulator of dopamine receptors--apomorphine on autogenic motor activity. It was shown that clonidine injections result in a significant increase of this activity, whereas apomorphine slightly decreases the latter. The data obtained in the present work together with those described earlier for l-DOPA effects, suggest that double regulation of autogenic activity is realized at early stages of ontogenesis. This regulation includes excitatory noradrenergic mechanisms and inhibitory influences which are mediated presumably by dopaminergic systems of the brain.
在对3日龄大鼠幼崽进行的实验中，研究了去甲肾上腺素受体激动剂可乐定和多巴胺受体激动剂阿扑吗啡对自发运动活动的影响。结果表明，注射可乐定可导致这种活动显著增加，而阿扑吗啡则使其略有降低。本研究获得的数据与先前描述的左旋多巴作用的数据一起表明，在个体发育的早期阶段实现了对自发活动的双重调节。这种调节包括兴奋性去甲肾上腺素能机制和可能由脑多巴胺能系统介导的抑制性影响。
