Bursian A V, Timofeeva O P, Voskresenskiĭ V O
Zh Evol Biokhim Fiziol. 1987 Nov-Dec;23(6):755-60.
In 1-, 2- to 3-, 7- to 8-, and 10-day old intact and spinal rat puppies, studies have been made of the effect of l-DOPA (100 mg/kg, intraperitoneally) on autogenic periodic motor activity in the gastrocnemius muscle. In 1- to 3-day old pups, strong stimulating effect was observed up to a prolonged continuous activity for 5-10 or even more minutes. This effect decreases with age. Traces of the inhibitory effect are observed at early stages in the form of total decrease of the activity. The inhibitory effect increases with age. In all spinal animals, at the background of a decreased activity, stimulating effect of l-DOPA was predominantly observed. Age peculiarities of the effect of l-DOPA are discussed in relation to ontogenetic development of catecholaminergic innervation in rats. It is suggested that stimulating effect of l-DOPA is associated with its action on the descending noradrenergic system, whereas the inhibitory one is mediated by the brain structures.
在1日龄、2至3日龄、7至8日龄以及10日龄的完整和脊髓损伤的幼鼠中，研究了左旋多巴（100毫克/千克，腹腔注射）对腓肠肌自主周期性运动活动的影响。在1至3日龄的幼崽中，观察到强烈的刺激作用，可导致长达5至10分钟甚至更长时间的持续活动。这种作用随年龄增长而减弱。在早期阶段，可观察到以活动完全减少形式出现的抑制作用痕迹。抑制作用随年龄增长而增强。在所有脊髓损伤的动物中，在活动减少的背景下，主要观察到左旋多巴的刺激作用。结合大鼠儿茶酚胺能神经支配的个体发育，讨论了左旋多巴作用的年龄特点。有人认为，左旋多巴的刺激作用与其对下行去甲肾上腺素能系统的作用有关，而抑制作用则由脑结构介导。
