Bursian A V, Timofeeva O P
Zh Evol Biokhim Fiziol. 1988 Jul-Aug;24(4):551-6.
In experiments on 2-3-, 7-8-, 10- and 16-day old rat pups, basic age differences have been observed in the effect of a precursor of catecholamine mediator, i.e. L-DOPA on the activity on the spinal and brain mechanisms of autogenic periodic motor excitation. Strong stimulation of the spinal motor rhythm was observed during the first week. At this period, supraspinal rhythm becomes even less evident. On further development, the effect is an opposite one. In 10- and 16-day rat pups, at the background of total inhibition of the spontaneous activity, administration of L-DOPA significantly increases the activity of supraspinal generator of the motor rhythm. The data obtained reveal ontogenetic changes in regulatory mechanisms of autogenic motor activity.
在对2 - 3日龄、7 - 8日龄、10日龄和16日龄大鼠幼崽进行的实验中，观察到儿茶酚胺介质前体（即左旋多巴）对自体周期性运动兴奋的脊髓和脑机制活动的影响存在基本的年龄差异。在第一周观察到脊髓运动节律受到强烈刺激。在此期间，脊髓上的节律变得更加不明显。在进一步发育过程中，效果则相反。在10日龄和16日龄的大鼠幼崽中，在自发活动完全受到抑制的背景下，给予左旋多巴可显著增加运动节律的脊髓上发生器的活动。所获得的数据揭示了自体运动活动调节机制的个体发生变化。
