Mühlenstedt D, Osmers F, Schneider H P
Arch Gynecol. 1978 Dec 29;226(4):341-6. doi: 10.1007/BF02119225.
A 35 year old patient with longstanding amenorrhea-galactorrhea due to a pituitary macroadenoma has been observed for a period of more than 2 years. During this time tumour expansion was radiologically evident. A full term pregnancy was responsible for most of the tumour growth. Following postpartum period Bromocriptin treatment led to considerable regression of the adenoma. Recalcification of sella structures and an involuted sella volume was radiologically evident. With reference to the experimental investigations of Lloyd (1975) and following the suggestions of L'Hermite (1977) and Vaidya (1977) this tumour regression is interpreted as being due to the antimitotic effect of Bromocriptin via inhibition of c-AMP and DNA.
一名35岁因垂体大腺瘤导致长期闭经-溢乳的患者已被观察了两年多。在此期间，肿瘤扩大在影像学上很明显。一次足月妊娠是肿瘤大部分生长的原因。产后使用溴隐亭治疗导致腺瘤明显缩小。蝶鞍结构重新钙化和蝶鞍体积缩小在影像学上很明显。参照劳埃德（1975年）的实验研究，并遵循勒米特（1977年）和瓦伊迪亚（1977年）的建议，这种肿瘤缩小被解释为是由于溴隐亭通过抑制环磷酸腺苷（c-AMP）和DNA产生的抗有丝分裂作用。
