脂滴在啮齿动物和人类代谢性疾病中的作用。
The role of lipid droplets in metabolic disease in rodents and humans.
机构信息
Obesity and Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA.
出版信息
J Clin Invest. 2011 Jun;121(6):2102-10. doi: 10.1172/JCI46069. Epub 2011 Jun 1.
Abstract
Lipid droplets (LDs) are intracellular organelles that store neutral lipids within cells. Over the last two decades there has been a dramatic growth in our understanding of LD biology and, in parallel, our understanding of the role of LDs in health and disease. In its simplest form, the LD regulates the storage and hydrolysis of neutral lipids, including triacylglycerol and/or cholesterol esters. It is becoming increasingly evident that alterations in the regulation of LD physiology and metabolism influence the risk of developing metabolic diseases such as diabetes. In this review we provide an update on the role of LD-associated proteins and LDs in metabolic disease.
摘要
脂滴（LDs）是细胞内储存中性脂质的细胞器。在过去的二十年中，我们对 LD 生物学的理解有了显著的增长，同时，我们对 LD 在健康和疾病中的作用的理解也有了显著的增长。从最简单的形式来看，LD 调节中性脂质（包括三酰甘油和/或胆固醇酯）的储存和水解。越来越明显的是，LD 生理学和代谢调节的改变会影响患代谢疾病（如糖尿病）的风险。在这篇综述中，我们提供了关于 LD 相关蛋白和 LD 在代谢性疾病中的作用的最新信息。
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