用于检测结直肠癌转移和复发的单克隆免疫闪烁成像术。
Monoclonal immunoscintigraphy for detection of metastasis and recurrence of colorectal cancer.
机构信息
School of Medicine, University of Belgrade, Clinical Center of Serbia, Visegradska 26, 11000 Belgrade, Serbia.
出版信息
World J Gastroenterol. 2011 May 21;17(19):2424-30. doi: 10.3748/wjg.v17.i19.2424.
AIM
To assess the clinical role of monoclonal immunoscintigraphy for the detection of metastasis and recurrence of colorectal cancer.
METHODS
Monoclonal immunoscintigraphy was performed in patients operated on for colorectal adenocarcinoma suspected of local recurrence and metastatic disease. The results were compared with conventional diagnostics.
RESULTS
Immunoscintigraphic investigation was done in 53 patients. Tumor recurrence occurred in 38 patients, and was confirmed by other diagnostic modalities in 35. In 15 patients, immunoscintigraphic findings were negative, and confirmed in 14 with other diagnostic methods. Comparative analysis confirmed good correlation of immunoscintigraphic findings and the results of conventional diagnostics and the level of tumor marker carcinoembryonic antigen. Statistical analysis of parameters of radiopharmaceutical groups imacis, indimacis and oncoscint presented homogenous characteristics all of three radiopharmaceuticals. The analysis of immunoscintigraphic target focus was clearly improved using tomography.
CONCLUSION
Immunoscintigraphy is highly specific and has a good predictive value in local recurrence of colorectal cancer.
目的
评估单克隆免疫闪烁显像在结直肠癌转移和复发检测中的临床作用。
方法
对怀疑局部复发和转移性疾病的结直肠腺癌手术患者进行单克隆免疫闪烁显像。将结果与常规诊断方法进行比较。
结果
对 53 例患者进行了免疫闪烁显像检查。38 例患者发生肿瘤复发，其中 35 例经其他诊断方法证实。在 15 例患者中，免疫闪烁显像结果为阴性，其中 14 例经其他诊断方法证实。对比分析证实免疫闪烁显像结果与常规诊断方法和肿瘤标志物癌胚抗原水平具有良好的相关性。对 imacis、indimacis 和 oncoscint 三种放射性药物组的放射性药物参数进行统计学分析，结果表明所有三种放射性药物均具有同质特征。断层扫描明显改善了免疫闪烁显像目标焦点的分析。
结论
免疫闪烁显像在结直肠癌局部复发中具有高度的特异性和良好的预测价值。
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